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· Before or At Conception
· Inherited disorders (such as phenylketonuria, Tay-Sachs disease, neurofibromatosis, hypothyroidism, and fragile X syndrome)
· Chromosome abnormalities (such as Down syndrome)
· During Pregnancy
· Severe maternal malnutrition
· Infections with HIV, cytomegalovirus, herpes simplex, toxoplasmosis, rubella virus
· Toxins (such as alcohol, lead, and methyl mercury)
· Drugs (such as phonation, valproate, isotretinoin, and cancer chemotherapy)
· Abnormal brain development (such as pore cephalic cyst, grey matter heterotopias, and encephalocele)
· Preeclampsia and multiple births
· During Birth
· Insufficient oxygen (hypoxia)
· Extreme prematurity
· After Birth
· Brain infections (such as meningitis and encephalitis)
· Severe head injury
· Malnutrition of the child
· Severe emotional neglect or abuse
· Toxins (such as lead and mercury)
· Brain tumors and their treatments
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